Identification and function of bacterial small RNAs in human circulation

Linyao Fan; Wenjiong Xie; Qingyi Shen; Chang Xu; Yang Lu; Jiao Cang; Yaoyao Ma; Qipeng Zhang

doi:10.55092/exrna20240007

Review

Open Access

Identification and function of bacterial small RNAs in human circulation

Linyao FanWenjiong XieQingyi ShenChang XuYang LuJiao CangYaoyao MaQipeng Zhang^∗

Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), NJU Institute of AI Biomedicine and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, China

* qpzhang@nju.edu.cn

Volume
Volume 6 Issue 2, 2024
Citation
Fan L, Xie W, Shen Q, Xu C, Lu Y, et al. Identification and function of bacterial small RNAs in human circulation. ExRNA 2024(2):0007, https://doi.org/10.55092/exrna20240007.
DOI
10.55092/exrna20240007
Copyright
Copyright2024 by the authors. Published by ELSP.

Abstract

Small RNAs (sRNAs) are a class of post-transcriptional regulators in bacteria and eukaryotes. Recent advancements in small RNA sequencing have unveiled the presence of bacterial sRNAs in human body fluids, indicating that these sRNAs might be transmitted into the host organism via extracellular vesicles (EVs). This discovery underscores the potential of bacterial sRNAs as novel communicators in host-microbe interactions and as biomarkers for disease diagnosis and progression. Additionally, the review delves into the role of bacterial sRNAs within EVs, highlighting their significance in mediating bacterial virulence and modulating host immune responses. The emerging application of sRNAs in the early detection of bacteremia presents a novel approach to diagnosing and managing bacterial infections, showing the potential of sRNAs as a tool in clinical settings.

Keywords

bacterial small RNA (sRNA); extracellular vesicle (EV); human circulation

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