Therapeutic potential of plant-derived amiRNAs: challenges and strategies

Xuanlin Li; Yuan Wang; Zhi Hong

doi:10.55092/exrna20240003

Review

Open Access

Therapeutic potential of plant-derived amiRNAs: challenges and strategies

State Key Laboratory of Pharmaceutical Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, 163 Xianlin Ave, Nanjing, Jiangsu 210023, China

* zhihong@nju.edu.cn

Volume
Volume 6 Issue 1, 2024
Citation
Li X, Wang Y, Hong Z. Therapeutic potential of plant-derived amiRNAs: challenges and strategies. ExRNA 2024(1):0003, https://doi.org/10.55092/exrna20240003.
DOI
10.55092/exrna20240003
Copyright
Copyright2024 by the authors. Published by ELSP.

Abstract

Small RNAs (sRNAs) are potent and accurate genetic regulators capable of targeting a diverse range of genes in eukaryotes. In recent years, the sRNA-based RNA interference (RNAi) technique has emerged as a promising strategy for modifying pathological processes by targeting specific genes or gene families, thereby promoting RNAi-based precise medical therapy. Notably, plant-derived miRNAs have shown promise in the treatment of various disorders, including cancer, neurodegenerative diseases, and infectious diseases. This review examines the therapeutic potential of plant-derived natural miRNAs and artificial miRNAs (amiRNAs), especially sourced from edible plants like crops and herbs. In addition, we discuss the challenges and strategies of utilizing amiRNAs in the therapeutic application and highlight the essential factors for effectively producing desired miRNA mimics in plants.

Keywords

artificial miRNAs; RNAi therapy; sRNA drugs; plant; oral administration; cross-kingdom regulation

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References

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