Long short-term memory network with exponential gating mechanism: a deep learning approach for cardiovascular stroke risk stratification
1 Department of Computer Science, VNIT, Nagpur 440010, India
2 Bharati Vidyapeeth’s College of Engineering, New Delhi 110063, India
3 Stroke Diagnostic and Monitoring Division, AtheroPoint™, Roseville 95661, USA
4 Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), Cagliari 09100, Italy
5 University Center for Research & Development, Chandigarh University, Mohali 140413, India
6 Symbiosis Institute of Technology, Symbiosis International (Deemed University), Nagpur 440008, India
7 Department of Electrical and Computer Engineering, Idaho State University, Pocatello 83209, USA
  • DOI
    10.55092/bi20250006
  • Copyright
    Copyright2025 by the authors. Published by ELSP.
Abstract

Cardiovascular disease (CVD) is the leading cause of global health issues which requires swift and accurate risk assessment techniques. Present-day risk calculators together with machine learning (ML) models have performed inadequately when it comes to reliability and comprehension of results. We produced a complex deep learning (DL) framework which builds Extended Long Short-Term Memory networks using an exponential gating mechanism (xLSTMeg). The new architecture design controls feature variations while extracting long-term dependencies through increased performance. A Random Forest Regression (RFR) evaluated the most important features while focusing on the top influential biomarkers, which eliminates redundant features. Performance is evaluated using cross-validation protocol and scientifically validated using DL explainability paradigm. The exponential gating mechanism achieved superior performance in CVD risk stratification by at least 6% compared to conventional long short-term memory (cLSTM) and other ML models. Analysis showed that RFR allows the system to benefits most from the 64% most significant features. The system yielded better results by employing DL algorithms which SHapley Additive exPlanations (SHAP) analysis proved essential features for risk prediction. Our study concludes that our proposed xLSTMeg architecture with optimized features for CVD risk assessment achieves better robustness and enhanced accuracy.

Keywords

cardiovascular disease risk; feature extraction; Long Short-Term Memory with exponential gating; scientific validation and performance evaluation

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