Cancer research is undergoing a profound transformation. Advances in molecular and cellular biology, genomics, immunology, engineering, and computational science have reshaped our understanding of cancer as a complex, multiscale disease. Yet the gap between biological discovery and durable clinical benefit remains a central challenge. Addressing this gap increasingly requires integration across disciplines, technologies, and conceptual frameworks. Advanced Cancer Research is an international, peer-reviewed, open-access journal publishing original cancer research spanning basic, translational, and clinical investigation. The journal prioritizes studies that provide mechanistic depth, introduce conceptual or technological innovation, or offer system-level insight into cancer biology and therapy, with particular emphasis on work that bridges disciplinary boundaries and advances translational relevance.