Microneedles, as arrayed delivery platforms composed of micron-sized needles, have attracted extensive attention in the field of transdermal drug delivery in recent years. They are capable of delivering not only small and large molecules but also therapeutic and diagnostic agents, while offering the advantage of good patient compliance. Meanwhile, microneedles also provide new ideas for the delivery of active ingredients derived from Traditional Chinese Medicine (TCM). This article comments on a recent study by Lang and Xie et al. published in Advanced Science. In this work, a metabolically stable derivative of cordycepin and its microneedle system were successfully developed, and the system exhibited potent in vivo activity in psoriasis management. By integrating structural optimization of TCM-derived compounds with microneedle delivery technology, this study offers a useful reference for the transdermal delivery of active ingredients from TCM. To further promote clinical translation, this article suggests that the mechanical strength of microneedles should be monitored as a critical quality attribute during scale-up manufacture, and that their storage stability should be systematically investigated, particularly the hygroscopic behavior of polyvinylpyrrolidone (PVP)-based microneedles and the necessity of low-humidity storage conditions.